There's a tech note from FTDI on how to install their drivers for windows 10. One step I forgot above is to right click on the driver package and install as administrator.
It just occurred to me that one thing that's probably different between us and you is that we likely have UAC disabled on our machines (developers usually disable UAC). You probably have it still enabled. Perhaps it's getting in the way? Maybe try running vixen as administrator and see if it can then open the port? Or try at least temporarily disabling UAC (then reboot) and try vixen again to see if it can access the port.
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